Advanced fertility treatments refer to medical procedures and technologies used to assist individuals or couples in achieving pregnancy when they face difficulties conceiving naturally. These treatments often come into play after basic fertility treatments, such as medication and lifestyle changes, have not been successful.
Fertility preservation is the preservation of reproductive potential for future use, often used by individuals facing fertility challenges. Common methods include oocyte cryopreservation, embryo cryopreservation, sperm cryopreservation, ovarian tissue cryopreservation, and hormonal preservation. It's crucial to consult with healthcare providers, fertility specialists, or endocrinologists to determine the most suitable approach.
Preimplantation Genetic Testing (PGT) is a genetic testing method used during in vitro fertilization (IVF) to assess embryos' genetic status. It helps select embryos free from specific genetic disorders or chromosomal abnormalities, increasing pregnancy rates and reducing the risk of genetic diseases. PGT-A, PGT-M, PGT-SR, and PGT for polygenic disorders assess the genetic predisposition of embryos to complex conditions. Despite its costs, accuracy, ethical concerns, and emotional challenges, PGT is regulated by professional organizations.
Preimplantation Genetic Screening (PGS) is a genetic test used during in vitro fertilization (IVF) to screen embryos for chromosomal abnormalities. It improves implantation chances and reduces miscarriage risk by selecting embryos with the correct number of chromosomes. PGS works through IVF, analyzing cells using next-generation sequencing or array comparative genomic hybridization.
Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) is a genetic test used during in vitro fertilization to screen embryos for specific conditions, reducing the risk of inherited diseases, but should be consulted with a fertility specialist.
Fertility rejuvenation procedures are medical interventions to improve fertility potential in individuals or couples experiencing age-related decline in fertility or other reproductive health factors. Common procedures include ovarian rejuvenation, ovarian reserve testing, lifestyle modifications, surgical interventions, endometrial rejuvenation and experimental therapies. The effectiveness of these procedures depends on individual factors and should be evaluated with a fertility specialist.
Platelet-Rich Plasma (PRP) treatment is a medical procedure that extracts and concentrates platelets from blood to promote healing and regeneration. It is used in orthopedics, sports medicine, dermatology, and reproductive medicine and fertility treatments. PRP can improve sperm quality, ovarian function, egg quality, endometrial receptivity, and overall reproductive outcomes. Further research is needed.
Stem cell therapy is a growing field of research aiming to provide new treatments for infertility. Techniques include Spermatogonial Stem Cells (SSCs) for male infertility, Ovarian Stem Cells (OSCs) for female infertility, and Endometrial Regenerative Cells (ERCs) for endometrial regeneration. However, ethical, legal, and regulatory considerations remain, including the source of stem cells and clinical applications.
Ovarian tissue preservation is a fertility preservation technique that involves surgically removing a portion of the ovary cortex and disseminating it into small fragments. The frozen tissue is stored in a cryopreservation facility, which can be thawed and re-implanted when a woman is ready to conceive or wishes to become pregnant.